Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral malaria.

C R Newton1, T T Hien, N White

  • 1Neurosciences Unit, Institute of Child Health, London, United Kingdom. cnewton@kilifi.mimcom.net

Journal of Neurology, Neurosurgery, and Psychiatry
|September 16, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy, safety, and tolerability of arbaclofen in Autistic children and adolescents, the AIMS-2-TRIALS-CT1: a randomized, double-blind, placebo-controlled phase II trial.

EClinicalMedicine·2026
Same author

A Validation Study of the Paediatric Non-Urgent Risk Assessment Management and Nurse Escort Assessment (PaNURAMA) Tool for Paediatric Inter-Hospital Transfers.

Emergency medicine Australasia : EMA·2025
Same author

Weathering the Storm: The Impact of Weather Events, Lockdowns and Holidays on Oncology and General Emergency Presentations to a United Kingdom Tertiary Centre-A 7.5-year Review.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Disease-specific wearable sensor algorithms for profiling activity, gait, and balance in individuals with Charcot-Marie-Tooth disease type 1A.

Journal of the peripheral nervous system : JPNS·2023
Same author

Prognostic evaluation in patients with advanced cancer in the last months of life: ESMO Clinical Practice Guideline.

ESMO open·2023
Same author

Delivery Models and Health Economics of Supportive Care Services in England: A Multicentre Analysis.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023

Cerebral malaria, a major cause of encephalopathy, presents complex pathogenesis and neurological complications. Effective treatment relies on antimalarial drugs, but resistance necessitates exploring new interventions and managing co-existing conditions.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Cerebral malaria is the most frequent non-traumatic encephalopathy globally.
  • Its pathogenesis is complex, involving multisystem dysfunction with differing presentations in adults and children.
  • Neurological complications and sequelae are increasingly recognized.

Purpose of the Study:

  • To review the heterogeneous pathogenesis of cerebral malaria.
  • To discuss current and potential interventions, focusing on antimalarial drugs.
  • To highlight the need for managing co-morbidities and further research into neurological damage.

Main Methods:

  • Literature review of recent studies on cerebral malaria pathogenesis and treatment.
  • Analysis of clinical presentations and pathophysiological differences between age groups.

Related Experiment Videos

  • Evaluation of the impact of antimalarial drugs and emerging drug resistance.

    • Main Results:

    • Antimalarial drugs are crucial for outcomes, but resistance is a significant concern.
    • Artemisinin derivatives show efficacy, yet alternative drugs may be necessary.
    • Prognosis is heavily influenced by managing complications like renal failure and acidosis.

    Conclusions:

    • Effective cerebral malaria management requires appropriate antimalarial therapy and comprehensive care for systemic complications.
    • Further research into the pathogenesis of coma and neurological damage is essential for developing ancillary treatments.
    • Addressing drug resistance and understanding neurological sequelae are critical for improving patient outcomes.