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Bilateral carotid dissection and factor V mutation: a second case.

C Cardon1, F Diemont, P Julia

  • 1Department of Cardiovascular Surgery, Hôpital Broussais, Paris, France.

Annals of Vascular Surgery
|September 16, 2000
PubMed
Summary
This summary is machine-generated.

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A young woman experienced carotid artery dissection linked to a Factor V Leiden mutation. While this is the second reported case, a direct causal link between Factor V Leiden mutation and carotid dissection remains unproven.

Area of Science:

  • Vascular Neurology
  • Genetics
  • Diagnostic Imaging

Background:

  • Cervical pain and sleep disturbance prompted investigation in a 38-year-old woman.
  • Spontaneous carotid artery dissection is a rare but serious condition.

Observation:

  • Doppler ultrasonography revealed bilateral internal carotid artery dissection.
  • Supraaortic arteriography confirmed the dissection.
  • A history of great saphenous vein thrombosis was noted.

Findings:

  • Genetic testing identified a heterozygotic Factor V Leiden mutation.
  • Cerebral lesions were absent on CT scans.
  • This represents the second reported case of carotid dissection in a patient with Factor V Leiden mutation.

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Implications:

  • The findings contribute to understanding risk factors for carotid artery dissection.
  • Further research is needed to establish a definitive link between Factor V Leiden mutation and carotid dissection.
  • This case highlights the importance of thrombophilia screening in young individuals with unexplained arterial events.