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Updated: Jul 17, 2026

Generation of Local CA1 γ Oscillations by Tetanic Stimulation
Published on: August 14, 2015
Paroxysmal starting and stopping of circulating waves in excitable media
Y Nagai1, H González, A Shrier
1Centre for Nonlinear Dynamics in Physiology and Medicine, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada.
Abstract:
Levels of intracellular Ca2+ were monitored using fluorescence from Ca2+-sensitive dyes in chick embryonic heart cells cultured in an annular geometry. There was spontaneous starting and stopping of reentrant waves of activity. The results are modeled using modified FitzHugh-Nagumo equations representing pacemakers embedded in a conducting medium. These results provide a potential mechanism for spontaneous abnormal cardiac rhythms in which there are rapid heart beats (tachycardias) that repetitively start and stop.
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