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Related Experiment Videos

Pseudomonas resistance to gentamicin.

A T Ramirez, F A Melendres, C A Capili

    Scandinavian Journal of Plastic and Reconstructive Surgery
    |January 1, 1979
    PubMed
    Summary
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    Burn wound infections are a major concern, with Pseudomonas aeruginosa often resistant to gentamicin. This study highlights a concerning decline in gentamicin sensitivity among burn pathogens over time.

    Area of Science:

    • Infectious Diseases
    • Burn Care
    • Microbiology

    Background:

    • Burn wound infections pose significant risks to patient recovery.
    • Topical antimicrobial therapies are crucial in managing burn wound infections.
    • Monitoring pathogen susceptibility is essential for effective treatment strategies.

    Purpose of the Study:

    • To analyze the microbial patterns and antibiotic susceptibility in burn wound infections.
    • To evaluate the effectiveness of topical mafenide and silver sulfadiazine therapies.
    • To assess trends in Pseudomonas aeruginosa gentamicin resistance.

    Main Methods:

    • Retrospective analysis of 288 burn wound cultures from 66 patients.
    • Identification of common bacterial pathogens.

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  • Testing of bacterial isolates for antibiotic susceptibility, particularly to gentamicin.

    • Main Results:

    • Pseudomonas aeruginosa was the most frequent pathogen (42%), followed by Klebsiella-Enterobacter (16%) and Staphylococcus aureus (13%).
    • Gentamicin sensitivity for Pseudomonas aeruginosa isolates was only 36.2% in the study period.
    • A significant decrease in gentamicin sensitivity was observed compared to previous years (42% in 1976, 85.7% in 1969-1973).

    Conclusions:

    • The declining sensitivity of Pseudomonas aeruginosa to gentamicin is a critical concern in burn wound management.
    • Current topical therapies may require reassessment in light of evolving antimicrobial resistance patterns.
    • Continuous surveillance of pathogen susceptibility is vital for optimizing burn patient care.