Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apomorphine and psychopathology.

S Lal, C E De la Vega

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Apomorphine, a dopamine agonist, did not cause psychiatric issues in men. Both apomorphine and placebo improved mood and reduced alcohol craving, with apomorphine uniquely increasing spontaneous erections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Breeding for resistance to downy mildews and stalk rots in maize.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Review article: the assessment and management of chronic severe gastrointestinal dysmotility in adults.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Seasonal characteristics of SO2, NO2, and CO emissions in and around the Indo-Gangetic Plain.

    Environmental monitoring and assessment·2013
    Same author

    Optimal patient education for cancer pain: a systematic review and theory-based meta-analysis.

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2013
    Same author

    Clinical and histological resolution of collagenous sprue following gluten-free diet and discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs).

    BMJ case reports·2013
    Same author

    Nutritional screening of elderly patients: a health improvement approach to practice.

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2013
    Same journal

    Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

    Journal of neurology, neurosurgery, and psychiatry·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Alcoholism is a significant public health concern.
    • Dopamine pathways are implicated in addiction and mood disorders.
    • Apomorphine is a dopamine receptor agonist with potential therapeutic applications.

    Purpose of the Study:

    • To investigate the safety and efficacy of apomorphine in men, particularly alcoholics.
    • To assess apomorphine's effects on mood, psychiatric symptoms, and alcohol craving.
    • To evaluate apomorphine's impact on psychomotor retardation and depressed mood.

    Main Methods:

    • A double-blind study involving 40 men, primarily alcoholics.
    • Administration of apomorphine HCl (1 mg) or placebo subcutaneously three times daily for 14 days.

    Related Experiment Videos

  • Assessment using the Hamilton Rating Scale, Zung Self Rating Scale, and Brief Psychiatric Rating Scale.

    • Main Results:

    • No development of endogenous depression or schizophrenic symptoms in any subjects.
    • Both apomorphine and placebo groups showed improvements in rating scale scores.
    • A significantly higher incidence of spontaneous penile erections was observed in the apomorphine group.
    • Subjective alcohol craving was eliminated in both treatment groups.
    • Apomorphine did not affect psychomotor retardation or depressed mood in patients with endogenous depression.

    Conclusions:

    • Apomorphine is well-tolerated in men, showing no adverse psychiatric effects.
    • Apomorphine and placebo demonstrate comparable efficacy in improving mood and reducing alcohol craving.
    • Apomorphine's pro-erectile effect warrants further investigation.
    • The findings suggest apomorphine may not be effective for acute treatment of endogenous depression symptoms.