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Bactericidal activity of quinupristin-dalfopristin against Staphylococcus aureus: clindamycin susceptibility as a
P C Fuchs1, A L Barry, S D Brown
1The Clinical Microbiology Institute, Wilsonville, Oregon, USA. cmi@hevanet.com
Antimicrobial Agents and Chemotherapy
|September 19, 2000
Abstract:
Of 516 Staphylococcus aureus strains tested, 97.1% were susceptible to quinupristin-dalfopristin, which was bactericidal for 22 (56%) of the 39 strains tested, comparable to vancomycin. All 17 clindamycin and macrolide-resistant strains were inhibited but not killed by quinupristin-dalfopristin, whereas all 22 clindamycin-susceptible strains (5 were macrolide resistant) were killed.