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[Changes in clinical diagnostic criteria for multiple system atrophy].

F Tison1

  • 1Service de neurologie, Groupe Hospitalier Sud, CHU de Bordeaux. ftison@neuro.u-bordeaux2.fr

Revue Neurologique
|September 19, 2000
PubMed
Summary

Multiple system atrophy (MSA) diagnosis requires reliable criteria. This review examines various diagnostic criteria for MSA, focusing on autonomic failure, parkinsonism, and cerebellar signs for accurate clinical assessment.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Medicine

Context:

  • Multiple system atrophy (MSA) presents with a variable combination of autonomic failure, parkinsonism, cerebellar, and pyramidal signs.
  • Pathologically, MSA is characterized by cell loss, gliosis, and oligodendroglial cytoplasmic inclusions in specific neurological systems.

Purpose:

  • To review and comment on the evolution of clinical diagnostic criteria for Multiple System Atrophy (MSA).
  • To highlight the need for sensitive and specific criteria that predict pathological diagnosis.
  • To discuss challenges in MSA diagnosis, including variable disease expression and defining key clinical features.

Summary:

  • Early criteria by Quinn (1989, revised 1994) proposed 'possible', 'probable', and 'definite' MSA diagnoses.

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  • Later consensus criteria (1998) emphasized autonomic failure and provided precise definitions for diagnostic domains and exclusion criteria.
  • The review critically analyzes the progression and refinement of MSA diagnostic standards.

    • Impact:

    • Improved clinical diagnosis of Multiple System Atrophy (MSA) at various disease stages.
    • Enhanced ability to predict pathological findings through validated clinical criteria.
    • Facilitation of research and clinical trials by standardizing patient cohorts.