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Candida albicans RIM101 pH response pathway is required for host-pathogen interactions.

D Davis1, J E Edwards, A P Mitchell

  • 1Department of Microbiology, Columbia University, New York, New York 10032, USA. dd251@columbia.edu

Infection and Immunity
|September 19, 2000
PubMed
Summary
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The RIM101 pathway is essential for Candida albicans virulence in mice. This pathway, including Rim8p, is crucial for fungal pathogenesis and damaging host cells during systemic candidiasis.

Area of Science:

  • Mycology
  • Pathogenesis
  • Molecular Biology

Background:

  • Candida albicans environmental adaptability is key to its pathogenicity.
  • The RIM101 pathway regulates gene expression and morphology in response to pH.
  • Its role in vivo pathogenesis remains to be fully elucidated.

Purpose of the Study:

  • To determine the in vivo necessity of the RIM101 pathway for C. albicans pathogenesis.
  • To investigate the function of Rim8p in the context of the RIM101 pathway during infection.

Main Methods:

  • Utilized mouse model of hematogenously disseminated systemic candidiasis.
  • Assessed virulence, kidney pathology, and endothelial cell damage in C. albicans mutants.
  • Employed an activated allele (RIM101-405) to study pathway rescue.

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Main Results:

  • rim101(-) and rim8(-) mutants exhibited significantly reduced virulence and kidney pathology.
  • These mutants displayed impaired endothelial cell damage in situ.
  • RIM101-405 suppressed rim8(-) defects, rescuing virulence and pathogenicity markers in vivo.

Conclusions:

  • The RIM101 pathway is indispensable for C. albicans virulence in a systemic infection model.
  • Rim8p functions upstream to activate Rim101p, which is critical for pathogenesis.
  • This pathway represents a potential target for antifungal therapies.