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Conflicts with the somatopause.

A A Toogood1, S M Shalet

  • 1Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|September 19, 2000
PubMed
Summary

Organic disease causes growth hormone (GH) deficiency in older adults, distinct from age-related decline. This condition impacts body composition and bone turnover, even if bone density remains normal.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Research

Background:

  • Growth hormone (GH) secretion naturally declines with age.
  • Previous studies suggested GH secretion might cease in adults over 60.
  • The distinction between age-related decline and disease-induced GH deficiency in the elderly was unclear.

Purpose of the Study:

  • To investigate if organic hypothalamic-pituitary axis disease causes GH deficiency distinct from age-related decline in adults over 60.
  • To assess the impact of organic GH deficiency on body composition and bone metabolism in elderly individuals.

Main Methods:

  • Studied adults aged 61-88 years with and without GH deficiency due to organic hypothalamic-pituitary axis disease.
  • Measured GH secretion, serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) levels.
  • Assessed body composition (fat mass, lean mass), bone turnover markers (osteocalcin, deoxypyridinoline), and bone mineral density (BMD).

Main Results:

  • Patients with organic GH deficiency showed a 90% reduction in GH secretion compared to controls.
  • Serum IGF-I was reduced in GH-deficient patients, but only 17% fell below the normal range.
  • Increased fat mass and reduced bone turnover markers were observed in GH-deficient patients, but lean mass and BMD were not significantly different from controls.

Conclusions:

  • Organic hypothalamic-pituitary axis disease causes GH deficiency in older adults, separate from the natural aging process.
  • This specific GH deficiency is associated with increased fat mass and reduced bone turnover, but not decreased bone density.
  • Findings highlight the need to differentiate pathological GH deficiency from age-related changes in the elderly.

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