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Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
S G Gray1, S Kytölä, T Matsunaga
1Laboratory for Molecular Development and Tumor Biology, Experimental Alcohol and Drug Addiction Research Section, Dept. of Clinical Neuroscience, Karolinska Institute, CMM, L8 01, Stockholm, S-171 76, Sweden.
Abstract:
Hepatoblastoma is a malignant paediatric liver tumour. In order to approach the genetic background of this malignancy we have screened a panel of eighteen cases from Europe and Japan for chromosomal imbalances using comparative genomic hybridization (CGH). The most frequent losses included chromosomal regions 13q21-q22 (28%) and 9p22-pter (22%), while the most frequent gains occurred on 2q23-q24 (33%), 20q (28%) and 1q24-q25 (28%). A significant difference in CGH alterations between the tumours from patients of Caucasian and Japanese was revealed where loss of 13q was found only in the Japanese samples. In conclusion, the findings indicate several candidate regions for suppressor genes and oncogenes potentially involved in the hepatoblastomas of different ethnic origin.