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Effect of estrogen on cerebral glucose metabolism in postmenopausal women
J L Eberling1, B R Reed, J E Coleman
1Center for Functional Imaging Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA. eberling@cfi.lbl.gov
Neurology
|September 20, 2000
Abstract:
PET was used to evaluate the effect of estrogen use on regional cerebral glucose metabolism in postmenopausal women. Women receiving estrogen replacement therapy (ERT+), women not receiving estrogen (ERT-), and women with AD were studied. The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity.