Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cochlear nuclei revisited.

W B Dublin1

  • 1Laboratory of Auditory Pathology, Veterans Administration Medical Center, Martinez, Calif., USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|November 1, 1982
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reticulum.

Archives of pathology·2010
Same author

Central auditory pathology.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1986
Same author

The cochlear nuclei--pathology.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1985
Same author

Cerebral pseudoatrophy and computed tomography: two illustrative case reports.

Surgical neurology·1978
Same author

The auditory pathology of anoxia.

Otolaryngology·1978
Same author

The combined correlated audiohistogram. Incorporation of the superior ventral cochlear nucleus.

The Annals of otology, rhinology, and laryngology·1976

Spheroid cells in the cochlear nuclei (CN) are crucial for hearing. Injury to these cells, particularly in the superior ventral cochlear nucleus (SVCN) around 4,000 Hz, can cause central hearing loss.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Neuroanatomy

Background:

  • The cochlear nuclei (CN) are key structures in the auditory pathway, located at the brainstem's junction of the medulla and pons.
  • The CN comprises dorsal (DCN), superior ventral (SVCN), and inferior ventral (IVCN) parts.
  • Spheroid cells, identified in the SVCN, are second-order neurons central to auditory processing.

Purpose of the Study:

  • To investigate the role of spheroid cells in the SVCN and their susceptibility to injury.
  • To correlate spheroid cell injury patterns with specific auditory frequencies and potential hearing loss.
  • To establish a link between neuroanatomy and audiology for understanding central hearing loss.

Main Methods:

  • Anatomical identification of spheroid cells within the SVCN of human cochlear nuclei.

Related Experiment Videos

  • Mapping of the SVCN to frequency strata, from ventral low frequencies to dorsal high frequencies.
  • Analysis of spheroid cell injury patterns, particularly in relation to anoxia and specific frequency levels (e.g., 4,000 Hz).

    • Main Results:

    • Spheroid cells are predominantly found in the SVCN and are integral to the ascending auditory pathway.
    • The SVCN exhibits a tonotopic organization, with low frequencies ventral and high frequencies dorsal.
    • Spheroid cells demonstrate particular vulnerability to anoxic injury, especially around the 4,000 Hz frequency region.

    Conclusions:

    • Injury to spheroid cells in the SVCN is a significant factor in central-type hearing loss.
    • The susceptibility of spheroid cells to anoxia at specific frequencies, like 4,000 Hz, provides insights into the mechanisms of auditory dysfunction.
    • Comparing injury patterns with audiometric data can aid in diagnosing and understanding central hearing loss.