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Updated: Jul 21, 2026

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
Published on: February 25, 2011
Genetic perturbations that reveal tertiary conformation of tRNA precursor molecules
Abstract:
The ubiquity of tRNA-like conformations in tRNA precursors of prokaryotes provides a common structural basis for precursor recognition by the maturation enzymes. This design eliminates need for multiple enzymes to achieve the maturation of different precursors. Moreover, the requirement of this specific conformation for maturation guards against the production of potentially deleterious mutant tRNAs.
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