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Apolipoprotein E genotype in Spanish schizophrenic patients.
N Durany1, P Riederer, F F Cruz-Sánchez
1Institute of Neurological and Gerontological Sciences, International University of Catalunya, Barcelona, Spain. ndurany@csc.unica.edu
Psychiatric Genetics
|September 20, 2000
Summary
This study found no significant link between Apolipoprotein E (ApoE) genotype and schizophrenia in Spanish patients. ApoE
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Apolipoprotein E (ApoE) plays roles in neuronal repair.
- Schizophrenia has a genetic component and can involve cognitive impairment.
- ApoE's role in Alzheimer's dementia suggests a potential link to schizophrenia.
Purpose of the Study:
- To investigate the association between Apolipoprotein E (ApoE) genotype and schizophrenia.
- To explore potential correlations between ApoE isoforms and clinical characteristics of schizophrenia.
Main Methods:
- Genotyping of Apolipoprotein E (ApoE) alleles in 114 Spanish schizophrenic patients and 94 healthy controls.
- Analysis of ApoE genotype distribution in relation to schizophrenia diagnosis and clinical subgroups.
Main Results:
- No statistically significant association was found between ApoE genotype and schizophrenia.
- Minor, non-significant trends observed for ApoE4 in early-onset schizophrenia and ApoE2 in patients with poor neuroleptic response.
- No significant differences in ApoE allele frequencies between patients and controls.
Conclusions:
- The study does not support a role for Apolipoprotein E (ApoE) in the etiology of schizophrenia.
- Cognitive impairment in schizophrenia is unlikely related to the same ApoE mechanisms as in Alzheimer's disease.