Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A threshold method to improve standardized uptake value reproducibility.

J R Lee1, M T Madsen, D Bushnel

  • 1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Nuclear Medicine Communications
|September 20, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventative interventions for postoperative delirium after intraabdominal surgery - A systematic review and meta-analysis of randomized trials.

American journal of surgery·2025
Same author

Diagnostic Performance of PET and Perfusion-Weighted Imaging in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature.

AJNR. American journal of neuroradiology·2020
Same author

Impact of oral preoperative and perioperative immunonutrition on postoperative infection and mortality in patients undergoing cancer surgery: systematic review and meta-analysis with trial sequential analysis.

BJS open·2020
Same author

Clinical audit training improves undergraduates' performance in root canal therapy.

European journal of dental education : official journal of the Association for Dental Education in Europe·2017
Same author

Oral tolerance modulates the skin transcriptome in mice with induced atopic dermatitis.

Allergy·2017
Same author

Effects of third fragment size and displacement on non-union of femoral shaft fractures after locking for intramedullary nailing.

Orthopaedics & traumatology, surgery & research : OTSR·2016
Same journal

A scoring model based on lymph node-to-primary tumor standardized uptake value ratio aids in classifying neck nodal metastasis risk in patients with head and neck cancer treated by surgery.

Nuclear medicine communications·2026
Same journal

Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion studies as marker of stress adequacy by semiquantitative analysis of acquired single-photon emission computed tomography/computed tomography images.

Nuclear medicine communications·2026
Same journal

Diagnostic performance of 18F-prostate-specific membrane antigen-1007 PET/computed tomography and multiparametric MRI in prostate cancer: application of the PRIMARY score in a sub-Saharan African cohort.

Nuclear medicine communications·2026
Same journal

Short breath-hold PET imaging in hypermetabolic pulmonary nodules.

Nuclear medicine communications·2026
Same journal

Radiolabeling and physicochemical characterization of terbium-161 DOTATATE.

Nuclear medicine communications·2026
Same journal

Diagnostic performance and quantitative characterization of PET/computed tomography in peritoneal deposits assessment.

Nuclear medicine communications·2026
See all related articles

Standardized uptake values (SUV) in 18F-FDG PET imaging vary with measurement methods. A new technique using a fixed fraction of maximum counts offers more stable and reliable SUV results, independent of lesion size and shape.

Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Standardized uptake values (SUV) are crucial for quantifying 18F-FDG uptake in tumors.
  • Current SUV calculation methods exhibit systematic differences among investigators.
  • Variability in SUV measurement can impact diagnostic accuracy and treatment monitoring.

Purpose of the Study:

  • To compare SUVmax and SUVmean calculation methods.
  • To investigate an alternative SUV technique using a fixed fraction of maximum counts.
  • To assess the impact of region size and shape on SUV measurements.

Main Methods:

  • Simulated PET projections of the thorax with spherical lesions were generated.
  • SUVmax, SUVmean, SUV0.6max, and SUV0.75max were calculated for simulated and clinical lesions.

Related Experiment Videos

  • Four observers independently determined SUVs from six clinical 18F-FDG PET studies.

    • Main Results:

    • SUVmean showed a 57% decrease compared to SUVmax in simulations.
    • SUV0.6max and SUV0.75max decreased by 23% and 14%, respectively.
    • SUVmean varied by 35% with region size, while SUV0.6max and SUV0.75max varied by less than 3%.

    Conclusions:

    • The proposed fixed-fraction SUV technique yields results independent of lesion region size and shape.
    • This method provides more stable and reliable SUV measurements compared to current approaches.
    • The findings are expected to improve the consistency of 18F-FDG PET quantitative analysis.