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Activity and immobilization after eccentric exercise: II. Serum CK.

S P Sayers1, P M Clarkson, J Lee

  • 1Department of Exercise Science, University of Massachusetts, Amherst 01003, USA. ssayers@excsci.umass.edu

Medicine and Science in Sports and Exercise
|September 20, 2000
PubMed
Summary

Immobilizing exercised muscles significantly reduces serum creatine kinase (CK) activity post-exercise. This suggests reduced muscle damage removal and lymphatic transport during recovery, impacting CK levels.

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Area of Science:

  • Exercise physiology
  • Muscle damage markers

Background:

  • Eccentric exercise causes muscle damage, indicated by elevated serum creatine kinase (CK).
  • Muscle activity during recovery influences the extent of muscle damage and repair processes.

Purpose of the Study:

  • To investigate the impact of varying muscle activity levels on serum CK activity following high-force eccentric exercise.
  • To determine if muscle immobilization affects post-exercise serum CK levels.

Main Methods:

  • Twenty-six male volunteers underwent high-force eccentric elbow flexor exercise.
  • Participants were assigned to immobilization, control, or light exercise groups for 4 days post-exercise.
  • Serum CK activity and arm activity (using CSA devices) were monitored before and during the treatment period.

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Main Results:

  • A significant group-by-time interaction was observed for serum CK activity (P < 0.05).
  • The immobilization group exhibited significantly lower peak serum CK activity (668 IU) compared to control (4230 IU) and light exercise (2740 IU) groups.
  • Activity levels differed significantly between groups, with immobilization showing the lowest counts (529 counts x min(-1)).

Conclusions:

  • Immobilization of exercised muscle during recovery significantly reduces serum CK activity.
  • This reduction may be attributed to decreased CK removal from damaged muscle and/or diminished lymphatic transport.
  • Muscle activity level is a critical factor influencing serum CK response after eccentric exercise.