Search research articles

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Nanoliter liquid metering in microchannels using hydrophobic patterns

Handique¹, Burke, Mastrangelo

¹Department of Chemical Engineering, The University of Michigan, Ann Arbor 48109-2136, USA.

Analytical Chemistry

|September 20, 2000

Summary

Accurate nanoliter liquid metering is achieved in microchannels using hydrophobic treatments and air pressure. This method precisely splits and controls liquid volumes for various applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Survey of the Free and Conjugated Myricetin and Quercetin Content of Red Wines of Different Geographical Origins.

Journal of agricultural and food chemistry·2001

Same author

Not Nelson's Obelisk

Scientific American·2000

Same author

Pathology of Transmyocardial Angiogenesis and Arteriogenesis.

Current interventional cardiology reports·2000

Same author

The Ununited Scaphoid:Prognostic Factors in Delayed and Nonunions of the Scaphoid.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·2000

Same author

Health risks of cigar smoking

JAMA·2000

Same author

Introduction.

Current surgery·2000

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Area of Science:

Microfluidics
Surface Chemistry
Materials Science

Background:

Accurate liquid handling at the nanoliter scale is crucial for many scientific disciplines.
Existing microfluidic techniques face challenges in precise volume control and droplet manipulation.

Purpose of the Study:

To develop a novel method for accurate nanoliter liquid metering within microchannels.
To demonstrate precise control over liquid drop volumes using surface properties and air pressure.

Main Methods:

Fabrication of hydrophobic regions on hydrophilic microchannels using patterned metal masks and silane treatment.
Controlled filling of microchannels and subsequent splitting of liquid drops via air injection through side channels.
Characterization of metered liquid volumes ranging from 0.5 to 125 nanoliters.

More Related Videos

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Related Experiment Videos

Last Updated: Jul 19, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Main Results:

Successful demonstration of nanoliter-sized liquid drop metering with high precision and accuracy.
Experimental results for metered volumes show good agreement with theoretical pressure predictions.
The technique enables reliable manipulation of liquid volumes within microfluidic systems.

Conclusions:

The developed technique offers a robust and accurate method for nanoliter liquid metering in microfluidics.
This approach has potential applications in diagnostics, drug delivery, and chemical synthesis.
Combining surface treatments with air pressure provides effective control over microscale liquid volumes.