Related Experiment Video
Updated: Aug 1, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Significance of commissural calcification on outcome of mitral balloon valvotomy
N Sutaria1, D B Northridge, T R Shaw
1Department of Cardiology, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
Insights
Commissural calcification, assessed by echocardiography, predicts mitral balloon valvotomy outcomes. Mild calcification improves valve area and symptoms in suitable patients, indicating valve replacement for severe cases.
Area of Science:
- Cardiology
- Echocardiography
- Valvular Heart Disease
Background:
- Mitral balloon valvotomy is a treatment for mitral stenosis.
- Predicting the success of mitral balloon valvotomy is crucial for patient management.
- Commissural calcification is a feature seen on echocardiography of the mitral valve.
Purpose of the Study:
- To assess the impact of commissural calcification on mitral balloon valvotomy outcomes.
- To determine if commissural calcification predicts haemodynamic and symptomatic improvement.
Main Methods:
- Commissural calcification was graded (0-4) using transthoracic echocardiography.
- Mitral valve morphology was assessed using the Massachusetts General Hospital echo score.
- 300 patients (85 retrospective, 215 prospective) were studied.
Main Results:
- Commissural calcification grade predicted achieving a mitral valve area > 1.50 cm² without severe reflux.
- In patients with echo score ≤ 8, lower calcification grades showed significantly better valve area and symptom improvement.
- Patients with grade 0/1 calcification had a 67% success rate vs. 46% for grade 2/3 (p < 0.05).
Conclusions:
- Transthoracic echocardiography-assessed commissural calcification predicts outcomes in patients with "good" valves (echo score ≤ 8).
- Calcification of one or more commissures suggests <50% probability of achieving a valve area > 1.50 cm².
- Commissural calcification may indicate valve replacement for suitable surgical candidates.
Objective:
To evaluate the significance of commissural calcification, identified by transthoracic echocardiography, on the haemodynamic and symptomatic outcome of mitral balloon valvotomy.
Methods:
Commissural calcification was graded from 0-4 using parasternal short axis transthoracic views. The morphology of the mitral valve was also assessed using the Massachusetts General Hospital echo score.
Setting:
A tertiary cardiac centre in Scotland.
Patients:
300 patients were studied, 85 retrospectively and 215 prospectively. Mean (SD) age was 59.8 (12.7) years, range 13 to 87; 30% had been judged unsuitable for surgery. Median echo score was 6.8 (3.0), range 2-16.
Main Outcome Measures:
Immediate increase in mitral valve area and in New York Heart Association functional class 1-3 months after balloon valvotomy.
Results:
On univariate and multivariate analysis, commissural calcification grade was a significant predictor of achieving a mitral valve area of > 1.50 cm(2) without severe mitral reflux. Its influence was greatest in patients with an echo score = 8: those with commissural calcification grade 0/1 had significantly greater improvement in valve area and symptom status than those with grade 2/3; the proportions of patients achieving a final valve area of > 1.50 cm(2) were 67% and 46%, respectively (p < 0.05). In patients with an echo score of > 8, the influence of commissural calcification was smaller and not significant.
Conclusions:
Commissural calcification as assessed by transthoracic echocardiography is a useful predictor of outcome in patients with otherwise "good" valves (echo score = 8). Calcification of one commissure or more predicts a less than 50% probability of achieving a valve area above 1.50 cm(2) and is an indication for valve replacement in those who are suitable for surgery.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management

