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PLAC1, an Xq26 gene with placenta-specific expression.

M Cocchia1, R Huber, S Pantano

  • 1Laboratory of Genetics, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.

Genomics
|September 21, 2000
PubMed
Summary

Researchers identified PLAC1, a novel human X-linked gene crucial for placental development. This gene, expressed specifically in the placenta, plays a potential role in establishing the vital mother-fetus interface.

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Area of Science:

  • Genetics and Genomics
  • Developmental Biology
  • Reproductive Biology

Background:

  • A novel human X-linked gene, PLAC1, exhibits placenta-specific expression.
  • The gene's location and sequence have been fully characterized at cDNA and genomic levels.
  • A syntenic orthologue in mice was identified on the mouse X chromosome.

Purpose of the Study:

  • To characterize the novel human X-linked gene PLAC1.
  • To investigate the expression pattern and potential function of PLAC1 during placental development.
  • To explore the evolutionary conservation and protein homology between human and mouse PLAC1.

Main Methods:

  • Gene sequencing (cDNA and genomic levels).
  • Chromosomal mapping of the human gene and its mouse orthologue.

Related Experiment Videos

  • In situ hybridization using antisense mRNA in mouse embryos (7.5-14.5 days postcoitum).
  • Comparative sequence analysis of human and murine PLAC1 proteins.

    • Main Results:

    • PLAC1 gene maps to Xq26, telomeric to HPRT.
    • PLAC1 expression was detected in the ectoplacental cone, giant cells, and labyrinthine trophoblasts during mouse embryogenesis.
    • Human and mouse PLAC1 proteins show 60% identity and 77% homology, sharing functional domains (signal peptide, ZP3 interaction domain).

    Conclusions:

    • PLAC1 serves as a significant marker for placental development.
    • The protein's characteristics suggest a role in establishing the mother-fetus interface.
    • PLAC1 represents a conserved gene involved in mammalian placental formation.