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Medullary monoamine levels during experimental tooth movement
T Yamashiro1, H Kabuto, T Fukunaga
1Department of Orthodontics, Okayama University Dental School, 2-5-1, Shikata-cho, Okayama 700-8525, Japan.
Brain Research
|September 21, 2000
Abstract:
We investigated possible influence of nociception induced by experimental tooth movement on the medullary monoaminergic inhibitory systems. Forty-eight hours after the start of the experimental tooth movement, significant increases in dorsal serotonin (5-HT), dopamine (DA), norepinephrine (NE), 5-hydroxyindoleacetic acid (5-HIAA), and dihydroxyphenylacetic acid (DOPAC) levels were detected with ipsilateral dominance. These results suggest that the nociception induced by experimental tooth movement might be under modulation of serotonergic, noradrenergic, and dopaminergic systems.