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Updated: Sep 28, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in
D C Silveira1, G L Holmes, S C Schachter
1Department of Neurology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Enders #320, Boston, MA 02115, USA. silveira@a1.tch.harvard.edu
Abstract:
We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures.

