Prognostic factors for walking attainment in very low-birthweight preterm infants

S F Jeng1, K I Yau, H F Liao

  • 1School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 7 Chung-Shan South Road, Taipei, Taiwan. jeng@ha.mc.ntu.edu.tw

Early Human Development
|September 21, 2000
PubMed

Insights

Very low-birthweight (VLBW) preterm infants achieve walking later than normal term infants. Low gestational age, prolonged ventilation, and severe retinopathy of prematurity are linked to delayed walking in VLBW infants.

Area of Science:

  • Developmental Pediatrics
  • Neonatology
  • Motor Development

Background:

  • Preterm birth, especially very low-birthweight (VLBW), is associated with developmental challenges.
  • Gross motor development, including walking attainment, is a key milestone affected by prematurity.
  • Understanding factors influencing walking attainment in VLBW infants is crucial for early intervention.

Purpose of the Study:

  • To compare the age of walking attainment between VLBW preterm infants and normal term infants.
  • To identify variables associated with delayed walking attainment specifically in VLBW infants.
  • To explore potential pathways linking prematurity complications to motor development delays.

Main Methods:

  • Prospective cohort study comparing 96 VLBW infants and 82 term infants.
  • Gross motor development monitored at 6, 9, 12, and 18 months corrected age.
  • Multivariate proportional hazards regression used to analyze predictors of walking attainment.

Main Results:

  • VLBW infants attained walking significantly later (median 14 months) than term infants (median 12 months).
  • 11% of VLBW infants remained unable to walk by 18 months corrected age, compared to 0% of term infants.
  • Low gestational age, prolonged ventilation/oxygen therapy, and severe retinopathy of prematurity were significant predictors of delayed walking in VLBW infants.

Conclusions:

  • VLBW preterm infants are at increased risk for delayed walking attainment.
  • Low gestational age appears to be a primary factor, potentially mediated by respiratory distress and retinopathy of prematurity.
  • These findings highlight the need for close monitoring of motor development in VLBW infants and timely interventions.

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