Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activin signal transduction pathways.

S A Pangas1, T K Woodruff

  • 1Department of Neurobiology and Physiology, Northwestern University, O.T. Hogan, 4-150, 2153 N. Campus Drive, Evanston, IL 60208-2850, USA.

Trends in Endocrinology and Metabolism: TEM
|September 21, 2000
PubMed
Summary

Model organisms like flies and worms have significantly advanced our understanding of mammalian endocrine cell signaling pathways, revealing ligand properties and coactivators. This research highlights conserved pathways and complex regulatory interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric oncofertility care in limited versus optimum resource settings: results from 39 surveyed centers in Repro-Can-OPEN Study Part I & II.

Journal of assisted reproduction and genetics·2022
Same author

Correction to: A synopsis of global frontiers in fertility preservation.

Journal of assisted reproduction and genetics·2022
Same author

A synopsis of global frontiers in fertility preservation.

Journal of assisted reproduction and genetics·2022
Same author

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic.

Journal of assisted reproduction and genetics·2020
Same author

Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Primordial Follicle Transplantation within Designer Biomaterial Grafts Produce Live Births in a Mouse Infertility Model.

Scientific reports·2015

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Signal transduction pathways are crucial for mammalian endocrine cell function.
  • Conserved pathways exist between mammals, flies, and worms.
  • Model organisms offer powerful systems for studying these pathways.

Purpose of the Study:

  • To highlight the utility of model organisms in endocrine research.
  • To discuss the identification of ligands and coactivators.
  • To summarize advancements in understanding activin signaling.

Main Methods:

  • Comparative analysis of conserved signal transduction pathways.
  • Utilizing model organisms (flies, worms) for genetic and molecular studies.
  • Identification of signaling components and regulatory interactions.

Related Experiment Videos

Main Results:

  • Model organisms facilitated the elucidation of ligand properties.
  • Cellular coactivating molecules were rapidly identified in these systems.
  • Significant progress was made in understanding activin signaling components.

Conclusions:

  • Model organisms are invaluable for dissecting complex endocrine signaling.
  • Research in flies and worms has greatly expanded knowledge of activin pathways.
  • Ongoing studies are uncovering intricate regulatory mechanisms.