Related Experiment Videos
Actin cytoskeleton: thinking globally, actin' locally
1Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. lmlanier@mit.edu
Current Biology : CB
|September 21, 2000
Abstract:
A class of proteins dubbed pipmodulins bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.