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Cardiac imaging using Optison.

L N Clark¹, H C Dittrich

¹Molecular Biosystems, Inc., San Diego, California 92121, USA.

The American Journal of Cardiology

|September 21, 2000

Summary

Optison, an albumin microsphere contrast agent, improves echocardiography by enhancing endocardial delineation, especially in challenging stress tests. It aids in diagnosing heart conditions like ischemic coronary artery disease.

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Area of Science:

Cardiovascular Imaging
Medical Ultrasound
Pharmacology

Background:

Echocardiography often suffers from inadequate endocardial delineation without contrast agents.
This limitation affects the assessment of cardiac wall motion, particularly during stress echocardiography.
Optison (human albumin microspheres) is an injectable contrast agent designed to address these limitations.

Purpose of the Study:

To evaluate the utility of Optison in left-ventricular opacification and endocardial-border delineation.
To assess Optison's role in characterizing ischemic coronary artery disease.
To explore Optison's effectiveness in detecting perfusion and wall-motion abnormalities.

Main Methods:

Utilizing Optison as an injectable suspension contrast agent during echocardiographic examinations.
Conducting clinical studies to evaluate Optison in patients with acute and chronic ischemic coronary artery disease.
Assessing Optison's performance in detecting abnormalities during exercise and pharmacologic stress tests.

Main Results:

Optison demonstrates high acceptance rates for endocardial delineation in stress echocardiography.
The agent aids in differentiating artifacts from pathology within the cardiac cavity.
Studies are evaluating Optison's ability to detect perfusion and wall-motion abnormalities in ischemic heart disease.

Conclusions:

Optison enhances echocardiographic image quality for improved cardiac assessment.
The contrast agent shows promise in the evaluation of ischemic coronary artery disease.
Advancements in ultrasound technology will further augment Optison's diagnostic capabilities.

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