Related Experiment Video
Updated: Aug 3, 2026

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines
Published on: March 5, 2019
Histological changes induced by tibolone and estrogen/glucocorticoid on aging skin
D Kalogirou1, K Aroni, O Kalogirou
1Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Objective:
The aim of this study was to investigate the oral effects of tibolone and mestranol plus paramethasone on the skin of postmenopausal women. A second purpose was to determine endometrial thickness with transvaginal ultrasound.
Materials And Methods:
This randomized study was carried out in 39 healthy postmenopausal women. Skin biopsies were obtained from the thigh area by a single punch, before and after treatment, and the sections were evaluated. Current characteristics of both groups were measured at follow-up.
Results:
No gross differences were observed in size, distribution or imaging of collagen, elastic or reticular fibers. Statistically significant changes were found in the papillar dermis thickness. There were no statistically significant differences in the sonographic measurements.
Conclusion:
The estrogen/glucocorticoid combination provides a way to evaluate in parallel the cellular metabolism effects on the irreversible aging process. The current results encourage widening these observations of the possible advantage of this combination, in order to alleviate the cellular degenerative process.
Related Concept Videos
TGF - β Signaling Pathway
Tissue Renewal without Stem Cells
However, failure of such a system...
The Effect of Aging on Tissues
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Adaptation I: Introduction and Atrophy
Cellular Adaptation III: Hyperplasia

