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Updated: Aug 6, 2026
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
GH, IGF-I and binding proteins in altered nutritional states
1University of Sheffield Division of Clinical Sciences, Clinical Sciences Centre, Northern General Hospital, UK. r.j.ross@sheffield.ac.uk
Summary
Growth hormone (GH) impacts nutrition and growth, with anabolic effects beneficial for body composition. However, high doses in critically ill patients were linked to adverse outcomes, warranting careful consideration.
Area of Science:
- Endocrinology
- Metabolism
- Nutritional Science
Background:
- The intricate relationship between nutritional status and the growth hormone/insulin-like growth factor-I (GH/IGF-I) axis is well-established.
- Growth hormone (GH) plays a critical role in linear growth during childhood and maintaining body composition in adults.
- The anabolic and anti-catabolic properties of GH have led to its investigation as a therapeutic agent and its misuse by athletes.
Purpose of the Study:
- To review the influence of nutrition on the GH/IGF-I axis.
- To discuss the potential of GH as an anti-catabolic therapy.
- To highlight recent findings regarding high-dose GH therapy in critically ill patients.
Main Methods:
- Literature review focusing on the interplay between nutrition and the GH/IGF-I axis.
- Analysis of studies investigating GH's anabolic and anti-catabolic effects.
- Examination of clinical trial data, particularly concerning critically ill populations.
Main Results:
- Nutrition significantly modulates the GH/IGF-I axis at multiple levels.
- GH exhibits potent anabolic actions, contributing to growth and muscle maintenance.
- Recent studies indicate potential risks associated with high-dose GH therapy in critically ill patients, correlating with poor outcomes.
Conclusions:
- The GH/IGF-I axis is highly sensitive to nutritional status.
- GH holds promise as an anti-catabolic agent, but its application requires careful consideration of dosage and patient population.
- Further research is needed to elucidate the optimal use of GH, especially in catabolic states and critical illness.
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