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Solid-phase microextraction for the analysis of biological samples.

G Theodoridis1, E H Koster, G J de Jong

  • 1Department of Chemistry, Aristotle University of Thessaloniki, Greece.

Journal of Chromatography. B, Biomedical Sciences and Applications
|September 21, 2000
PubMed
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Solid-phase microextraction (SPME) offers a simple, solvent-free method for analyzing organic compounds in biological samples. This technique is increasingly used in clinical, forensic, and pharmaceutical analysis.

Area of Science:

  • Analytical Chemistry
  • Bioanalysis
  • Environmental Science

Background:

  • Solid-phase microextraction (SPME) is an advanced extraction technique for organic compounds.
  • SPME offers advantages like simplicity, cost-effectiveness, automation, and solvent-free operation.
  • Its application has expanded from environmental to food, biological, and pharmaceutical analyses.

Purpose of the Study:

  • To provide a comprehensive survey of SPME applications in biological sample analysis.
  • To categorize and review papers on the analysis of biologically active compounds using SPME.
  • To illustrate the impact of SPME across toxicological, forensic, clinical, biochemical, pharmaceutical, and natural product fields.

Main Methods:

  • Review and categorization of published research on SPME for biological samples.

Related Experiment Videos

  • Description of SPME features, modes, and coupling with chromatography (GC, LC, CE).
  • Discussion of SPME application in determining pharmaceuticals, drugs of abuse, and clinical/toxicological compounds.

    • Main Results:

    • SPME has been successfully coupled with GC, LC, and CE for analyzing biological matrices like urine, plasma, and hair.
    • The technique demonstrates significant potential and advantages over other sample pretreatment methods.
    • New trends in SPME applications for bioanalysis are highlighted.

    Conclusions:

    • SPME is a versatile and advantageous technique for the analysis of biological samples.
    • Its application in bioanalysis, particularly for pharmaceuticals and toxicological compounds, is expanding.
    • SPME shows great potential for future advancements in analytical chemistry and related fields.