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Related Experiment Videos

Tardive dystonia provoked by concomitantly administered risperidone.

H Tachikawa1, T Suzuki, Y Kawanishi

  • 1Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

Psychiatry and Clinical Neurosciences
|September 21, 2000
PubMed
Summary

Two cases show that risperidone may provoke tardive dystonia, a movement disorder. This can occur when switching to or increasing the dosage of risperidone, especially with other antipsychotics.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Antipsychotic medications are crucial for managing schizophrenia.
  • Extrapyramidal symptoms (EPS) are known side effects of antipsychotics.
  • Tardive dystonia is a specific type of movement disorder associated with long-term antipsychotic use.

Observation:

  • Two patients with schizophrenia developed retrocollis (a form of dystonia).
  • The first patient experienced retrocollis after her risperidone dosage was increased.
  • The second patient developed retrocollis after switching to risperidone from chlorpromazine.

Findings:

  • Both cases of retrocollis were attributed to tardive dystonia.
  • Risperidone, when initiated or increased, potentially provoked tardive dystonia in these patients.

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  • Concomitant use of risperidone with other antipsychotics may increase the risk.

    • Implications:

    • Clinicians should be aware of the potential for risperidone to induce tardive dystonia, even though it's considered to have a lower risk of EPS.
    • Careful monitoring is essential when initiating, increasing dosage, or switching to risperidone, particularly in patients with existing risk factors.
    • These cases highlight the importance of considering medication changes as a trigger for tardive syndromes.