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A selective coronary indicator dilution technique with fiberoptic recording.

U Sigwart, W Rutishauser

Zeitschrift Fur Kardiologie

|July 1, 1975

Summary

This study introduces a novel method for measuring myocardial circulation times, revealing shorter appearance times than previously thought. It also found prolonged transit times in patients with coronary artery disease, which decreased with higher heart rates.

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Area of Science:

Cardiology
Cardiovascular Physiology
Medical Imaging

Background:

Accurate measurement of myocardial circulation time is crucial for diagnosing cardiac conditions.
Previous methods for assessing coronary blood flow have limitations in precision and real-time monitoring.

Purpose of the Study:

To introduce and validate a new technique for precisely measuring myocardial circulation times.
To compare these measurements with existing estimates and assess their correlation with heart rate and coronary artery disease.

Main Methods:

Selective dye injections into the left coronary artery.
Instantaneous recording of dye passage in the coronary sinus using a fiberoptic catheter.
Analysis of dye dilution curves to determine appearance and mean transit times.

Main Results:

The new method yielded an appearance time of 2.2 +/- 0.8 seconds, shorter than previously estimated.
Patients with left coronary artery disease or myocardial disease exhibited significantly prolonged mean transit times (p < 0.01).
Mean transit time decreased significantly with increasing heart rate (p < 0.01) in all patients.
Deformed dye dilution curves were exclusively observed in cases of stenotic left coronary artery lesions.

Conclusions:

The described method provides accurate and sensitive measurements of myocardial circulation times.
Prolonged myocardial circulation times are indicative of coronary artery or myocardial disease.
Heart rate is a significant factor influencing myocardial circulation time, with higher rates leading to shorter transit times.

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