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Microbial genomics: from sequence to function.

I Schwartz1

  • 1New York Medical College, Valhalla, New York 10595, USA.

Emerging Infectious Diseases
|September 22, 2000
PubMed
Summary
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Genomic sequencing has advanced rapidly, with the shotgun approach now standard for deciphering entire genomes, including the human genome. This method, first shown with Haemophilus influenzae, is crucial for studying emerging infectious diseases.

Area of Science:

  • Genomics
  • Microbial genomics
  • Genomic sequencing technology

Background:

  • The human genome project marked the beginning of the genomics era.
  • Significant progress in sequencing other genomes has occurred, often overshadowed by the human genome project.
  • Microbial genome sequencing is vital for understanding emerging infectious diseases.

Purpose of the Study:

  • To review technological and scientific advances in genome sequencing since 1995.
  • To highlight the impact of the shotgun sequencing approach.
  • To discuss the relevance of microbial genomics for infectious disease research.

Main Methods:

  • Review of technological and scientific advancements in genome sequencing.
  • Focus on the shotgun sequencing approach for genome deciphering.

Related Experiment Videos

  • Analysis of progress since the Haemophilus influenzae genome sequence publication.

    • Main Results:

    • The shotgun approach is now the preferred method for sequencing most genomes.
    • This method was first demonstrated with the Haemophilus influenzae genome in 1995.
    • Advances have significantly improved the speed and efficiency of genome sequencing.

    Conclusions:

    • The shotgun sequencing method has revolutionized genomics.
    • Microbial genome sequencing plays a critical role in infectious disease research.
    • Continued advancements in sequencing technology promise further breakthroughs.