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Updated: Jul 30, 2026
05:58
Tissue Triage and Freezing for Models of Skeletal Muscle Disease
Published on: July 15, 2014
[Thrombophilia and Perthes' disease?]
J M Tusell Puigbert1, C Aulesa Martínez, M Aguirre Canyadell
1Hospital Materno-Infantil, Barcelona.
Anales Espanoles De Pediatria
|September 22, 2000
Summary
This study investigated thrombophilia in Perthes disease, finding no evidence of a clotting defect. Hemostasis analysis in pediatric patients did not support thrombosis as the cause of avascular necrosis.
Area of Science:
- Pediatric Orthopedics
- Hematology
- Vascular Biology
Context:
- Perthes disease, a childhood hip condition, has been hypothesized to stem from intravascular thrombosis.
- Congenital hemostatic disorders, such as thrombophilia or hyperfibrinolysis, have been implicated as potential causes.
Purpose:
- To investigate the prevalence of hemostasis and fibrinolysis abnormalities in pediatric patients diagnosed with Perthes disease.
- To determine if thrombogenesis defects contribute to the development of avascular necrosis of the hip joint.
Summary:
- Hemostasis and thrombophilia analyses were performed on 25 pediatric patients with Perthes disease and compared to a control group.
- One patient exhibited a mild protein S deficiency; all other patients presented with normal hemostasis parameters relative to age.
- Laboratory and epidemiological data did not support a thrombogenesis defect as the underlying cause of Perthes disease.
Impact:
- This research challenges the existing hypothesis linking thrombosis to Perthes disease etiology.
- Findings suggest that congenital thrombotic or fibrinolytic disorders are unlikely to be the primary cause of avascular necrosis in the hip joint in pediatric patients.
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