Related Experiment Video
Updated: Jul 30, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease
Published on: July 15, 2014
[Thrombophilia and Perthes' disease?]
J M Tusell Puigbert1, C Aulesa Martínez, M Aguirre Canyadell
1Hospital Materno-Infantil, Barcelona.
Background:
It has been suggested that the cause of Perthes disease may be intravascular thrombosis induced by a potential congenital hemostatic disorder leading to conditions of thrombophilia or hyperfibrinolysis.
Method:
Complete study of hemostasis with coagulation and antithrombin factors as well as study of thrombophilia and fibrinolysis in these patients could determine the prevalence of hemostasis and fibrinolysis in this group of patients.
Patients:
Twenty-five patients between the ages of 5 and 25 years during the study period and previously diagnosed with Perthes' disease underwent hemostasis and thrombophilia analysis. Results were compared with those of a control group.
Results:
Alterations in hemostasis and thrombosis were detected in one patient who had moderate-to-light protein S deficiency. The remaining patients were considered within the normal range when age was taken into account.
Conclusions:
Epidemiological and laboratory data from this group of pediatric patients and from the control group do not support the hypothesis that a thrombogenesis defect could be the underlying cause of avascular necrosis of the hip joint.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Peripheral Artery Disease I: Introduction
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease V: Postoperative Nursing Management
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

