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Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21)
S Paulien1, M Busson-Le Coniat, R Berger
1Institut de biologie et biochimie appliquée (IBBA), Université de Caen, Esplanade de la Paix, 14032 cedex, Caen, France.
Annales De Genetique
|September 22, 2000
Abstract:
Cytogenetic study of a young child with acute megakaryocytic leukaemia (AML-M7) has shown a karyotype with 49-50 chromosomes with one and two acquired extra chromosomes 21. Fluorescence in situ hybridization detected a minor clone with translocation t(1;21) and loss of a part of chromosome band 1p36. Trisomy and polysomy 21 are not uncommon in AML-M7. A more systematic search for chromosome 21 rearrangements in AML-M7 using FISH techniques is proposed.
