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Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function
1Department of Pharmacology and Experimental Therapeutics, and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 1901 Perdido Street, 70112, New Orleans, LA, USA. akapus@lsuhsc.edu
Abstract:
Orphanin FQ/Nociceptin (OFQ/N) is a peptide whose structure resembles that of the endogenous opioid peptides (endorphins). OFQ/N and its receptor are distributed in neural tissue and brain regions involved in the regulation of pituitary hormone release. Functional studies have shown that this peptide evokes a unique pattern of cardiovascular and renal excretory responses. This review will focus on the neural and humoral effects of OFQ/N and how this peptide may participate in the regulation of cardiovascular and renal function.
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