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Updated: Aug 10, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Interstitial cystitis: the painful bladder syndrome
R Doggweiler-Wiygul1, J Blankenship, S A MacDiarmid
1University of Tennessee, Memphis, Department of Urology, 1211 Union Avenue, Suite 340, Memphis, TN 38104, USA. rdoggweiler@yahoo.com
Abstract:
Interstitial cystitis (IC) is an enigmatic and frustrating condition to manage as a physician and to cope with as a patient. Many patients are declared as drug addicted and neurotic. Social status and number of sexual partners showed no correlation with incidence. Patients report moderate to excruciating pain in the suprapubic or vaginal area, urgency and frequency (up to 50 micturitions/d), and disruption of their social life. Diagnosis of IC is made by exclusion. Different pathophysiologic mechanisms have been proposed: changes in epithelial permeability, pelvic floor dysfunction, mastocytosis, activation of c-fibers, and increase of nerve growth factors and bradykinin. No single theory can explain IC.
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