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Related Experiment Videos

Interstitial cystitis: the painful bladder syndrome.

R Doggweiler-Wiygul1, J Blankenship, S A MacDiarmid

  • 1University of Tennessee, Memphis, Department of Urology, 1211 Union Avenue, Suite 340, Memphis, TN 38104, USA. rdoggweiler@yahoo.com

Current Review of Pain
|September 22, 2000
PubMed
Summary

Interstitial cystitis (IC) causes severe pelvic pain and urinary urgency, often misdiagnosed. Current research explores various potential causes, but no single theory fully explains this complex condition.

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Area of Science:

  • Urology
  • Pain Management
  • Gastroenterology

Background:

  • Interstitial cystitis (IC) presents significant management challenges for both physicians and patients.
  • Patients frequently experience debilitating suprapubic or vaginal pain, urinary urgency, and frequency, impacting social life.
  • IC diagnosis is often one of exclusion, with no definitive diagnostic markers.

Purpose of the Study:

  • To review the current understanding of interstitial cystitis (IC) pathophysiology.
  • To highlight the diagnostic difficulties and patient-reported symptoms associated with IC.
  • To discuss proposed, yet unconfirmed, mechanisms underlying IC.

Main Methods:

  • Literature review of proposed pathophysiologic mechanisms for interstitial cystitis.

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  • Analysis of patient-reported symptoms and diagnostic challenges.
  • Examination of factors influencing IC incidence.

    • Main Results:

    • No correlation found between social status or number of sexual partners and IC incidence.
    • Proposed mechanisms include epithelial permeability changes, pelvic floor dysfunction, mastocytosis, c-fiber activation, and increased nerve growth factors/bradykinin.
    • No single theory adequately explains the complexity of IC.

    Conclusions:

    • Interstitial cystitis remains an enigmatic condition with diverse proposed etiologies.
    • Effective management requires addressing the multifaceted symptoms and diagnostic complexities.
    • Further research is needed to elucidate the definitive pathophysiology of IC.