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L-Ascorbic acid and D-isoascorbic acid in a common cold survey.

K M Clegg, J M Macdonald

    The American Journal of Clinical Nutrition
    |September 1, 1975
    PubMed
    Summary
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    D-isoascorbic acid supplementation reduced cold incidence by 34% in student volunteers compared to L-ascorbic acid or placebo. This study investigated the effects of this vitamin C isomer on common cold symptoms.

    Area of Science:

    • Nutrition Science
    • Immunology
    • Biochemistry

    Background:

    • L-ascorbic acid (vitamin C) is essential for immune function.
    • D-isoascorbic acid is an isomer of L-ascorbic acid with limited vitamin C activity.
    • Investigating isomers can reveal specific biological functions.

    Purpose of the Study:

    • To evaluate the efficacy of D-isoascorbic acid in preventing common colds.
    • To compare the effects of D-isoascorbic acid, L-ascorbic acid, and placebo on cold incidence and duration.
    • To analyze potential influencing factors such as sex and smoking habits.

    Main Methods:

    • Double-blind, placebo-controlled study design.
    • Three groups of approximately 70 student volunteers.
    • Daily supplementation with 1g L-ascorbic acid, 1g D-isoascorbic acid, or placebo for 15 weeks.

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  • Recording of cold incidence and duration.

    • Main Results:

    • The D-isoascorbic acid group experienced 34% fewer colds compared to the L-ascorbic acid and placebo groups.
    • Analysis included stratification by sex and smoking status.
    • No significant differences were observed between L-ascorbic acid and placebo groups.

    Conclusions:

    • D-isoascorbic acid demonstrates potential in reducing the incidence of the common cold.
    • Further research is warranted to understand the specific mechanisms of D-isoascorbic acid's immune-modulating effects.
    • The antiscorbutic properties of D-isoascorbic acid do not appear to correlate with its observed effects on cold prevention.