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Related Experiment Videos

Visual Evoked Potential (VEP)--dependable marker for CNS affection in thyroid diseases.

S Misra1, R S Sinha, D C Jain

  • 1Deptt. of Neurology, Safdarjang Hospital, New Delhi.

The Journal of the Association of Physicians of India
|February 1, 1996
PubMed
Summary

Thyroid dysfunction significantly alters visual evoked potentials (VEP). Both P100 latency and amplitude were markedly affected in hypothyroid, hyperthyroid, and probable thyroiditis patients compared to controls.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Ophthalmology

Background:

  • Thyroid dysfunction is prevalent and can affect multiple organ systems.
  • Visual evoked potentials (VEP) assess the integrity of the visual pathway.
  • Alterations in VEP may indicate neurological complications of thyroid disease.

Purpose of the Study:

  • To investigate the impact of thyroid dysfunction on the P100 component of VEP.
  • To compare VEP parameters between patients with hypothyroidism, hyperthyroidism, probable thyroiditis, and healthy controls.

Main Methods:

  • VEP recordings were performed on 89 patients with thyroid dysfunction and 43 controls.
  • Measurements included P100 latency (in m.sec) and amplitude (in microvolts).
  • Statistical analysis compared VEP parameters across different thyroid status groups.

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Main Results:

  • Mean P100 latency was significantly prolonged in hypothyroid (110.69 m.sec), hyperthyroid (111.41 m.sec), and probable thyroiditis (109 m.sec) groups compared to controls (p < 0.005).
  • Mean P100 amplitude was significantly reduced in hypothyroid (1.34 µV) and probable thyroiditis (2.41 µV) groups, but increased in hyperthyroid (6.34 µV) group compared to controls (p < 0.005).

Conclusions:

  • Thyroid dysfunction is associated with significant alterations in VEP P100 latency and amplitude.
  • These findings suggest subclinical visual pathway dysfunction in thyroid disorders.
  • VEP may serve as a useful biomarker for assessing neurological involvement in thyroid disease.