Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise following heart transplantation.

R W Braith1, D G Edwards

  • 1College of Health and Human Performance, and College of Medicine (Division of Cardiology), University of Florida, Gainesville 32611, USA. rbraith@hhp.ufl.edu

Sports Medicine (Auckland, N.Z.)
|September 22, 2000
PubMed
Summary

Aggressive exercise rehabilitation, including endurance and resistance training, is crucial for heart transplant recipients (HTR) to regain function and improve quality of life. Structured exercise programs help reverse deconditioning and mitigate immunosuppression side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcium amelioration of aluminium toxicity effects on root hair development in soybean [Glycine max (L.) Merr.].

The New phytologist·2021
Same author

Dietary sodium and nocturnal blood pressure dipping in normotensive men and women.

Journal of human hypertension·2016
Same author

Rapid onset pressor and sympathetic responses to static handgrip in older hypertensive adults.

Journal of human hypertension·2014
Same author

Salt loading has a more deleterious effect on flow-mediated dilation in salt-resistant men than women.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2014
Same author

Exercise training improves endothelial function in resistance arteries of young prehypertensives.

Journal of human hypertension·2013
Same author

Direct renin inhibition improves parasympathetic function in diabetes.

Diabetes, obesity & metabolism·2012

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Rehabilitation Medicine

Background:

  • Heart transplantation has transitioned from experimental to a standard life-extending therapy for end-stage heart failure.
  • Short-term survival is less of a concern; focus has shifted to functional lifestyle and quality of life for heart transplant recipients (HTR).
  • HTR face unique challenges including pre-existing deconditioning, cardiac denervation, and immunosuppression therapy side effects.

Purpose of the Study:

  • To evaluate the efficacy of aggressive exercise rehabilitation in improving functional capacity and quality of life in HTR.
  • To investigate the role of endurance and resistance training in counteracting deconditioning and immunosuppression-related adverse effects in HTR.

Main Methods:

  • Review of existing evidence on exercise tolerance and training outcomes in HTR.

Related Experiment Videos

  • Analysis of studies examining the impact of endurance training on peak oxygen consumption (VO2peak) and peak heart rate.
  • Assessment of resistance training effects on bone mineral density (BMD), lean mass, and body fat in HTR.

    • Main Results:

    • Endurance training can help HTR approach age-matched norms for peak heart rate and VO2peak (up to 95% predicted), while untrained HTR remain significantly below predicted values (60-70%).
    • Resistance training effectively counters corticosteroid-induced osteoporosis and skeletal muscle myopathy, restoring BMD and increasing lean mass.
    • Untrained HTR experience significant bone density loss and muscle mass reduction post-transplantation.

    Conclusions:

    • Aggressive, structured exercise rehabilitation, encompassing both endurance and resistance training, is essential for HTR.
    • Exercise programs can significantly improve cardiovascular parameters, reverse deconditioning, and mitigate adverse effects of immunosuppression in HTR.
    • Further research is needed to fully elucidate the mechanisms behind exercise-induced improvements in HTR.