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Vasodilator effect of extract prepared from Uncariae ramulus on isolated rat aorta
H Goto1, I Sakakibara, Y Shimada
1Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
The American Journal of Chinese Medicine
|September 22, 2000
Abstract:
Uncariae ramulus et Uncus (URE) has a vasodilator effect. Its mechanism consists of not only endothelium-independent relaxation with Ca2+ channel blocking effect but also endothelium-dependent relaxation with nitric oxide. The active components are alkaloids and tannin contained in Uncariae ramulus et Uncus. They also show a superoxide dismutase-like effect and suppressed vasocontraction induced by xanthine and xanthine oxidase. These mechanisms may also influence vasodilatation by Uncariae ramulus et Uncus in vivo.