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Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
Published on: January 19, 2015
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase
V A Vaillancourt1, M M Cudahy, S A Staley
1Pharmacia, Kalamazoo, MI 49007, USA. valerie.a.vaillancourt@am.pnu.com
Abstract:
ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and hydroxy functionalities are required for activity. Substitution on the naphthalene ring has led to inhibitors with submicromolar IC50s against HCMV polymerase. These compounds have been found to be >100-fold selective for inhibition of HCMV polymerase versus human alpha polymerase and display antiviral activity in a cell-based plaque reduction assay.
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