Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet cyclic GMP responses to nitroglycerin.

D D Martin1, J S Tong, J D Parker

  • 1Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Cardiovascular Drugs and Therapy
|September 22, 2000
PubMed
Summary

Platelet cyclic guanosine monophosphate (GMP) does not reliably indicate nitroglycerin (GTN) effects or tolerance. This study found no change in platelet GMP with therapeutic GTN doses, questioning its use as a biochemical marker.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Widespread slow growth of acquisitive tree species.

Nature·2025
Same author

Neutron resonance absorption imaging of simulated high-level radioactive waste in borosilicate glass.

Scientific reports·2023
Same author

Accuracy and self-validation of automated bone age determination.

Scientific reports·2022
Same author

Personal perception and body awareness of dysmenorrhea and the effects of rhythmical massage therapy and heart rate variability biofeedback-A qualitative study in the context of a randomized controlled trail.

Complementary therapies in medicine·2019
Same author

Anaesthetic machine leak not detected by the universal leak test.

Anaesthesia·2019
Same author

Microbial Flora of Pond-Reared Shrimp ( Penaeus stylirostris , Penaeus vannamei , and Penaeus setiferus ).

Journal of food protection·2019

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cardiovascular Research

Background:

  • Platelet cyclic guanosine monophosphate (GMP) has been proposed as a biochemical marker for nitroglycerin (GTN) effects and tolerance.
  • Understanding GTN's biochemical impact is crucial for managing cardiovascular conditions and preventing tolerance development.

Purpose of the Study:

  • To investigate platelet cyclic GMP as a biochemical measure of tolerance to nitroglycerin (GTN).
  • To assess the relationship between platelet cyclic GMP levels and systolic blood pressure (SBP) during GTN therapy.

Main Methods:

  • Measured platelet cyclic GMP levels and SBP in subjects receiving transdermal GTN and control groups.
  • Administered acute sublingual GTN and conducted in vitro incubations with varying GTN concentrations.

Related Experiment Videos

  • Analyzed changes in platelet cyclic GMP and SBP in response to GTN administration and sustained therapy.

    • Main Results:

    • Acute transdermal GTN significantly decreased SBP, but SBP returned to baseline after 1 week of continuous therapy.
    • Platelet cyclic GMP levels showed no significant changes with acute or sustained transdermal GTN, or with sublingual GTN.
    • In vitro, platelet cyclic GMP increased only at a high GTN concentration (100 microM), not at therapeutic levels (22 nM).

    Conclusions:

    • Platelet cyclic GMP levels do not change in response to clinically relevant doses of GTN.
    • The use of platelet cyclic GMP as an index of GTN effects or tolerance requires cautious interpretation.
    • Current evidence does not support platelet cyclic GMP as a reliable biomarker for GTN therapy monitoring.