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Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora
H F Smit1, A J van den Berg, B H Kroes
1Section Medicinal Chemistry, Department of Pharmacy, Universiteit Utrecht, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. H.F.Smit@pharm.uu.nl
Journal of Natural Products
|September 23, 2000
Abstract:
Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhiza scrophulariaeflora and were identified as 25-acetoxy-2,3, 16,20-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25-pentahydroxy-9-methyl-19-norlanosta-5, 23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte proliferation at an IC(50) value of 1 microM.