A paradoxical idea of cancer's resolution
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Updated: Oct 13, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
Published on: June 7, 2024
G K Gogichadze1, A V Gedenidze
1Institute of Hematology and Blood Transfusion, Tbilisi, Georgia.
Abstract:
Polykaryocytes arising by means of fusion represent genetic deadlock. They cannot enter the S-phase of mitosis and they die quickly. A concept of cancer treatment proposes the conversion of tumor cells synchronously into the stage of unviable polykaryocytes, which leads to dissociation of the tumor substrate, reduction of the mass of tumor, and even to its resolution. Under echoscopic control, it is proposed to introduce into the tumor a solution ofwell-known fusogenic agents, such as polyethylene glycol (PEG) with the 15% dimethylsulfoxide (DMSO).
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