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Gonadal pathology in triploidy.

D E McFadden1, J T Pantzar, G P Jevon

  • 1Department of Pathology, Children's and Women's Health Centre of British Columbia and University of British Columbia, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|September 23, 2000
PubMed
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Triploidy can cause fetal and placental issues. While gonadal pathology is noted, overtly dysgenetic gonads are rare in triploidy cases, suggesting it

Area of Science:

  • Reproductive Medicine
  • Developmental Biology
  • Genetics

Background:

  • Triploidy is a chromosomal abnormality with significant fetal and placental pathology.
  • Gonadal development in triploidy is not well-characterized, with inconsistent reports on genital ambiguity.

Observation:

  • A case of diandric triploidy presented with severely dysgenetic gonads, including abnormal seminiferous tubules and stromal abnormalities.
  • A review of 51 triploid cases examined gonadal histology against age-matched controls.

Findings:

  • Minor, nonspecific gonadal changes are common in triploidy.
  • Overtly dysgenetic gonads, as seen in the index case, are rare in triploidy.

Implications:

  • This study clarifies the spectrum of gonadal pathology in triploidy.

Related Experiment Videos

  • Dysgenetic gonads are an uncommon feature of the triploidy phenotype, regardless of parental origin.