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Breast conservation in the 21st century
1Division of Radiation Oncology, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva, Switzerland. john.kurtz@hcuge.ch
European Journal of Cancer (Oxford, England : 1990)
|September 23, 2000
Summary
Breast conservation surgery is becoming more common due to early cancer detection and advances in imaging like MRI. These technologies enable personalized treatment planning and targeted therapies, improving outcomes for breast cancer patients.
Area of Science:
- Oncology
- Radiology
- Surgical Oncology
Background:
- Breast cancer diagnosis is occurring at earlier stages.
- Mastectomy lacks biological justification for many patients.
- Breast conservation is projected to increase in frequency.
Purpose of the Study:
- To explore the role of advanced imaging and interventional radiology in breast conservation.
- To discuss the impact of neoadjuvant therapies on surgical planning.
- To highlight future directions in personalized breast cancer treatment.
Main Methods:
- Review of current and emerging breast imaging techniques, focusing on Magnetic Resonance Imaging (MRI).
- Discussion of image-guided tumor mapping and interventional radiology procedures.
- Analysis of the influence of primary chemo- and chemoendocrine therapies.
Main Results:
- MRI aids in pre-therapy planning, patient selection for conservation, and estimation of residual tumor burden.
- Image-guided mapping allows for individualized local treatment and identification of subgroups not needing whole-breast treatment.
- Interventional radiology offers new focalized treatment options for small lesions.
Conclusions:
- Advanced imaging and interventional techniques are crucial for enhancing breast conservation strategies.
- Functional imaging, like MRI, is valuable for assessing response to medical therapy, enabling personalized radiotherapy and surgery.
- Technological advancements and biological response modifiers promise improved therapeutic ratios in radiation treatment.