Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple method for measuring severely reduced glomerular filtration rate.

A J White1, M Rachalewska, R R Venkannagari

  • 1Department of Nuclear Medicine, Medical University of Southern Africa, Medunsa. ajwhite@medunsa.ac.za

Journal of Nuclear Medicine Technology
|September 23, 2000
PubMed
Summary

A new, simpler method accurately measures severely reduced glomerular filtration rate (GFR) in most patients. This simplified GFR measurement is reliable even with edema or dehydration, but requires urine sampling if liver clearance is significant.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

Sleep disturbance and brain health in professional association footballers.

Frontiers in sports and active living·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025
Same author

First Measurement of ν_{e} and ν[over ¯]_{e} Charged-Current Single Charged-Pion Production Differential Cross Sections on Argon Using the MicroBooNE Detector.

Physical review letters·2025

Area of Science:

  • Nephrology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Accurate measurement of glomerular filtration rate (GFR) is crucial for managing chronic kidney disease.
  • Severely reduced GFR (below 30 mL/min) presents challenges for precise and simple quantification.
  • Conventional GFR measurement methods can be complex and time-consuming.

Purpose of the Study:

  • To develop and validate a simplified method for measuring severely reduced GFR.
  • To provide a more accessible GFR assessment tool for patients with advanced kidney impairment.

Main Methods:

  • Compared a novel simplified GFRn method using 99mTc-DTPA with the conventional 51Cr EDTA slope-intercept method.
  • Evaluated GFR in 24 patients with a GFR below 30 mL/min.

Related Experiment Videos

Main Results:

  • The simplified GFRn method demonstrated a high correlation (r=0.92) with the conventional method.
  • The method showed a slope of 0.97 and an intercept of 2 mL/min, indicating good agreement.
  • Acceptable error margins were observed in patients with edema or dehydration.

Conclusions:

  • The simplified GFRn method offers an accurate and practical approach for measuring severely reduced GFR.
  • The method is reliable for patients with fluid imbalances, but alternative urine sampling is needed for significant extrarenal clearance.
  • This simplified technique has the potential to improve GFR monitoring in clinical practice.