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Updated: Feb 8, 2026
09:24
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
15.2K
Tissue engineering via local gene delivery
1Selective Genetics, Inc., San Diego, CA 92121, USA. jbonadio@earthlink.net
Journal of Molecular Medicine (Berlin, Germany)
|September 23, 2000
Summary
Gene activated matrix (GAM) is a novel gene therapy for tissue engineering. This technology enables local gene delivery for wound healing and shows promise for treating osteoporotic hip fractures in the elderly.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Gene Therapy
Background:
- Gene activated matrix (GAM) is a pioneering gene therapy platform developed for tissue engineering.
- Its mechanism aligns with natural wound healing processes, suggesting broad applicability.
- Previous animal studies have demonstrated successful plasmid gene delivery across various tissues.
Purpose of the Study:
- To review the gene activated matrix (GAM) technology for local plasmid gene transfer.
- To explore the potential application of GAM in treating osteoporotic hip fractures in the elderly.
Main Methods:
- Review of existing literature on GAM technology and plasmid gene transfer.
- Analysis of animal study data demonstrating GAM's efficacy in different tissues.
- Evaluation of clinical need and feasibility for treating osteoporotic fractures.
Main Results:
- GAM has been successfully used for plasmid gene delivery in tendon, ligament, bone, muscle, skin, and nerve in animal models.
- The technology is well-suited for local gene delivery in diverse tissues and organs.
- Osteoporotic hip fracture treatment is identified as a primary clinical application for GAM.
Conclusions:
- GAM represents a versatile platform technology for local gene delivery in tissue engineering.
- Further development of GAM for treating osteoporotic hip fractures is warranted due to significant clinical need.
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