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Related Experiment Video

Updated: Jul 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

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Published on: January 9, 2015

Late-onset obsessive-compulsive disorder: a case series.

A P Weiss1, M A Jenike

  • 1Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA. aweiss@partners.org

The Journal of Neuropsychiatry and Clinical Neurosciences
|September 23, 2000
PubMed
Summary

Late-onset obsessive-compulsive disorder (OCD) is rare and may indicate an organic cause. Intracerebral lesions in the frontal lobes and caudate nuclei were found in most late-onset OCD cases studied.

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Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) typically emerges in early adulthood.
  • Late-onset OCD (after age 50) is uncommon and may suggest underlying organic causes.

Observation:

  • Researchers identified 5 cases of late-onset OCD within a large patient cohort.
  • The study focused on individuals whose OCD symptoms first appeared after age 50.

Findings:

  • Four out of five patients with late-onset OCD presented with intracerebral lesions.
  • Lesions were specifically located in the frontal lobes and caudate nuclei.
  • These findings align with existing theories on the pathogenesis of idiopathic OCD.

Implications:

  • Intracerebral lesions may play a role in the development of late-onset OCD.
  • Further research into the organic etiologies of late-onset OCD is warranted.
  • This study contributes to understanding the neurobiological underpinnings of OCD subtypes.