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Reticuloendothelial function in renal allograft recipients.

G Drivas, P R Uldall, N Wardle

    British Medical Journal
    |September 27, 1975
    PubMed
    Summary

    Phagocytic capacity of the reticuloendothelial system (R.E.S.) is increased in chronic renal failure. Post-transplant, R.E.S. function is reduced, especially with corticosteroid use, impacting immune response in renal transplant patients.

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    Area of Science:

    • Immunology
    • Nephrology
    • Transplantation

    Background:

    • The reticuloendothelial system (R.E.S.) plays a crucial role in immune surveillance and clearance.
    • Chronic renal failure (CRF) may alter R.E.S. phagocytic function.
    • Understanding R.E.S. function is vital in managing renal transplant recipients.

    Purpose of the Study:

    • To assess the phagocytic capacity of the R.E.S. in patients with CRF.
    • To evaluate changes in R.E.S. phagocytosis following renal transplantation.
    • To investigate the impact of corticosteroid therapy on R.E.S. function in transplant recipients.

    Main Methods:

    • Assessment of R.E.S. phagocytic capacity.
    • Comparison between patients with CRF, early post-transplant recipients, and long-term allograft recipients.
    • Analysis of R.E.S. function in relation to corticosteroid dosage.

    Main Results:

    • R.E.S. phagocytosis was found to be increased in patients with CRF.
    • Following renal transplantation, R.E.S. phagocytosis was moderately reduced compared to CRF patients.
    • High-dose corticosteroid treatment significantly reduced R.E.S. phagocytosis; long-term recipients on low-dose steroids also showed depressed function.

    Conclusions:

    • CRF enhances R.E.S. phagocytic activity.
    • Renal transplantation and subsequent corticosteroid therapy impair R.E.S. function.
    • Impaired R.E.S. function in transplant recipients may have implications for infection risk and immune response.

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