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[Analysis of HLA class I and II antigens composition in high-risk pregnancy]
A Mikłaszewicz1, O Szmigiel-Sipak, E Ronin-Walknowska
1Katedry i Zakładu Mikrobiologii i Immunologii PAM w Szczecinie.
Design:
We have analyzed the frequency of HLA class I and II antigens in high-risk pregnancy.
Material And Methods:
Altogether, 22 gravida hospitalized at the Department of Pathology of Pregnancy and Labour, Pomeranian Medical University in Szczecin formed group I (PE) with 12 cases of preeclampsia and group II with 10 cases of the antiphospholipid syndrome (APS). The control group included 40 multigravida. Typing of HLA class I and II antigens was done using the two-stage microcytotoxic test (NIH) of Mittal.
Results:
Antigen B35 was found more frequent in preeclampsia and antiphospholipid syndrome groups than in multigravida. Furthermore, a statistically significant difference in the frequency of homozygotes for the HLA-DR locus was noted between groups PE and APS on one hand, and controls on the other.
Conclusions:
Identical HLA-DR3, DR4 and DR5 antigens were found more frequently in preeclampsia, while identical DR4 and DR6 in the antiphospholipid syndrome.